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Quadplex Ultrasound™ – The Next Leap Beyond Duplex and Triplex Imaging
Four synchronized modes working together to make muscular perfusion visible, measurable, and actionable for orthopedic trauma care.
What is Quadplex Ultrasound™?
Quadplex Ultrasound™ is a four-in-one diagnostic platform that transforms standard ultrasound machines into real-time compartment monitoring tools. This breakthrough technology quantifies muscular perfusion to advance safer orthopedic traumatology and beyond.
By integrating four synchronized imaging modes, Quadplex creates a comprehensive physiological map that continuously tracks muscular perfusion and compartment pressures—providing objective, actionable data when every second counts in trauma care.
B-Mode Anatomy
Provides the baseline structural map for precise anatomical localization
Color Doppler Flow
Visualizes real-time blood distribution patterns throughout tissue
Spectral Doppler Waveform
Measures velocity and pulsatility for quantitative hemodynamic assessment
Compliance/Micromotion Mode
Detects tissue stiffness and pressure shifts using phase-sensitive micromotion analysis

Together, these modes create a "four-channel physiology map" that continuously tracks muscular perfusion and compartment pressures with unprecedented clarity.
How It Works
01
Signal Capture
Dual-frequency probes collect more than 10,000 signals per second, capturing high-resolution physiological data from multiple tissue depths simultaneously.
02
AI Processing
Proprietary algorithms leverage machine learning to convert raw ultrasonic data into intuitive, clinically meaningful visuals that reveal perfusion status in real time.
03
Multimodal Display
Side-by-side, layered, or overlaid views present anatomy, flow, waveform, and compliance data together—enabling comprehensive assessment at a glance.
04
Operator Simplicity
Minimal training required thanks to automated filters that reduce noise and user error, making advanced diagnostics accessible to clinicians across experience levels.
Key Differentiator
Unlike invasive needle-based compartment pressure measurement tools, Quadplex provides continuous, non-invasive monitoring with synchronized multimodal clarity. This eliminates patient discomfort while delivering superior diagnostic insight.
Clinical Advantages
Early Detection
Identifies rising compartment pressures before irreversible ischemic damage occurs, enabling timely fasciotomy decisions that preserve limb function and prevent amputation.
Objective Data
Replaces subjective "5 P's" clinical assessment (pain, pallor, pulselessness, paresthesia, paralysis) with quantifiable perfusion metrics and pressure measurements.
Continuous Monitoring
Tracks compartments over time with trending data, not just isolated snapshots—revealing pressure trajectory and perfusion changes throughout the care continuum.
Patient Comfort
No needles, no calibration, no repeated punctures. Completely non-invasive approach reduces infection risk and eliminates the pain associated with traditional monitoring.
Clinical Evidence: Studies show delayed acute compartment syndrome (ACS) diagnosis leads to amputation rates exceeding 60% according to the National Trauma Data Bank. Quadplex directly addresses this critical diagnostic gap.
Platform Flexibility
Quadplex Ultrasound™ is designed as a Software as a Medical Device (SaMD) platform, offering unprecedented flexibility for healthcare systems and device manufacturers worldwide. Our regulatory pathway aligns with FDA SaMD Guidance for rapid clearance.
This hardware-agnostic approach enables seamless integration across existing infrastructure while supporting next-generation innovation in point-of-care diagnostics.
Hardware-Agnostic Architecture
Runs on existing ultrasound consoles—whether cart-based systems, handheld devices, or wearable monitoring platforms—maximizing facility investment.
Dual-Frequency Probes
Supports advanced compliance sensing through specialized transducer technology, enabling unprecedented tissue characterization and pressure detection.
OEM Integration Ready
Licensing-ready for major ultrasound manufacturers including GE Healthcare, Philips, and Siemens Healthineers—accelerating global adoption through trusted partnerships.
Scalable SaMD Architecture
Built as Software as a Medical Device for rapid regulatory clearance, cloud-based updates, and seamless deployment across healthcare networks.
Beyond Acute Compartment Syndrome
Quadplex is a platform technology with transformative applications across multiple medical specialties. While our initial focus addresses acute compartment syndrome in orthopedic trauma, the same four-mode framework extends diagnostic capabilities throughout healthcare.
Intracranial Pressure Monitoring
Non-invasive ICP assessment for traumatic brain injury, hydrocephalus, and neurocritical care applications.
ARIA Drug Safety
Amyloid-related imaging abnormalities monitoring via CerebroPulse for Alzheimer's therapeutic trials and clinical management.
Burn Perfusion Assessment
Real-time tissue viability evaluation to guide debridement decisions and optimize healing outcomes in severe thermal injuries.
Organ Congestion Detection
Liver and kidney perfusion monitoring for heart failure, cirrhosis, and acute organ dysfunction management.
Transplant Viability
Pre-transplant organ assessment and post-operative perfusion monitoring to detect early rejection or vascular complications.
Sepsis Perfusion Monitoring
Microcirculatory assessment in septic shock to guide resuscitation strategies and predict organ failure risk.
Neuromuscular Triage
Rapid differentiation of neurological versus vascular compromise in emergency and critical care settings.
Obstetrics Applications
Placental perfusion assessment for high-risk pregnancies, fetal growth restriction, and preeclampsia management.

Each application leverages the same proven four-mode Quadplex framework, extending life-saving impact from trauma care through neurology, critical care, and beyond.
Quadplex Ultrasound™ is Redefining Diagnostic Clarity
From orthopedic trauma care to broader healthcare innovation, our technology makes muscular perfusion visible, measurable, and actionable.
TraumaPulse Biosystems provides AI and ultrasonic-enabled muscular perfusion data for orthopedic traumatology trials (Research Use Only), broader healthcare research, and clinical screening purposes—advancing the future of precision diagnostics.
Our Mission
Quantifying muscular perfusion to advance safer orthopedic traumatology and transform patient outcomes across medical specialties.
Our Commitment
Delivering regulatory-compliant, clinically validated solutions that empower physicians with objective data for life-saving decisions.
Our Vision
Making advanced perfusion monitoring accessible at every point of care—from emergency departments to operating rooms worldwide.